rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We show that E23K is also associated with decreased insulin secretion in glucose-tolerant control subjects, supporting a mechanism whereby beta-cell dysfunction contributes to the common form of type 2 diabetes.
|
15111507 |
2004 |
rs5215
|
|
|
0.860 |
GeneticVariation |
BEFREE |
We performed a comprehensive meta-analysis for KCNJ11 rs5219, rs5210, rs5215, and ABCC8 rs757110 to evaluate the effect of these regions on genetic susceptibility for type 2 diabetes.
|
24065655 |
2013 |
rs5210
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We performed a comprehensive meta-analysis for KCNJ11 rs5219, rs5210, rs5215, and ABCC8 rs757110 to evaluate the effect of these regions on genetic susceptibility for type 2 diabetes.
|
24065655 |
2013 |
rs5218
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated whether the E23K (G→A, rs5219) or A190A (C→T, rs5218) variations in KCNJ11 are associated with early-onset T2DM and blood pressure in the Chinese population.
|
25725792 |
2015 |
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We included 44 original studies published by June 2014 in a meta-analysis of the p.E23K association with T2DM.
|
25955821 |
2015 |
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We have genotyped three single nucleotide polymorphisms associated with type 2 diabetes in a large type 1 diabetic family collection of European descent: Gly972Arg in the insulin receptor substrate 1 (IRS1) gene, Glu23Lys in the potassium inwardly-rectifying channel gene (KCNJ11), and Pro12Ala in the peroxisome proliferative-activated receptor gamma2 gene (PPARG2).
|
14988278 |
2004 |
rs5215
|
|
|
0.860 |
GeneticVariation |
BEFREE |
We found a lower risk of prediabetes and type 2 diabetes combined with coffee intake among individuals with the GT/TT of IGF2BP2 rs4402960, GG/GC of CDKAL1 rs7754840, or CC of KCNJ11 rs5215, which are known to be related to type 2 diabetes in East Asians.
|
25755232 |
2015 |
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We conclude that the polymorphisms of the SUR1 gene predicted the conversion from impaired glucose tolerance to type 2 diabetes and that the effect of these polymorphisms on diabetes risk was additive with the E23K polymorphism of the Kir6.2 gene.
|
15579791 |
2004 |
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Using the random-effects model, we found a significant association between E23K (rs5219) polymorphism and T2D risk with per-allele odds ratio of 1.13 (95% confidence interval: 1.10-1.15; p<10(-5)).
|
22082043 |
2012 |
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Using MGA, some common gene variants were found to have little (<5%) but significant impact on the heritability of T2D related QTs [KCNJ11 (rs5219), p=0.004]; [IGF2BP2 (rs4402960), p=0.02]; [SLC30A8 (rs13266634), p=0.05]; [CAPN10 (rs2975760), p=0.031]; [FTO (rs8050136), p=0.023]; [FTO (rs9939609), p=0.018] and [SLC30A8 (rs13266634), p=0.05].
|
24993573 |
2014 |
rs2285676
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Triglycerides, DBP and KCNJ11 rs2285676 are predictors of the DPP-4 inhibitor treatment response in T2DM patients.
|
27249660 |
2016 |
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we genotyped 1279 Japanese subjects (556 men and 723 women), who underwent computed tomography for measurements of visceral fat area (VFA) and subcutaneous fat area (SFA) for the following single-nucleotide polymorphisms (SNPs): NOTCH2 rs10923931, THADA rs7578597, PPARG rs1801282, ADAMTS9 rs4607103, IGF2BP2 rs1470579, VEGFA rs9472138, JAZF1 rs864745, CDKN2A/CDKN2B rs564398 and rs10811661, HHEX rs1111875 and rs5015480, TCF7L2 rs7901695, KCNQ1 rs2237892, KCNJ11 rs5215 and rs5219, EXT2 rs1113132, rs11037909, and rs3740878, MTNR1B rs10830963, DCD rs1153188, TSPAN8/LGR5 rs7961581, and FTO rs8050136 and rs9939609.
|
22377712 |
2012 |
rs5215
|
|
|
0.860 |
GeneticVariation |
BEFREE |
To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we genotyped 1279 Japanese subjects (556 men and 723 women), who underwent computed tomography for measurements of visceral fat area (VFA) and subcutaneous fat area (SFA) for the following single-nucleotide polymorphisms (SNPs): NOTCH2 rs10923931, THADA rs7578597, PPARG rs1801282, ADAMTS9 rs4607103, IGF2BP2 rs1470579, VEGFA rs9472138, JAZF1 rs864745, CDKN2A/CDKN2B rs564398 and rs10811661, HHEX rs1111875 and rs5015480, TCF7L2 rs7901695, KCNQ1 rs2237892, KCNJ11 rs5215 and rs5219, EXT2 rs1113132, rs11037909, and rs3740878, MTNR1B rs10830963, DCD rs1153188, TSPAN8/LGR5 rs7961581, and FTO rs8050136 and rs9939609.
|
22377712 |
2012 |
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ11), rs1801282 (PPARγ), rs10811661 (CDKN2A/2B), rs13266634 (SLC30A8), rs12779790 (CDC123/CAMK1D), rs7903146 (TCF7L2), rs9282541 (ABCA1) and rs13342692 (SLC16A11) polymorphisms in the genetic background of Maya population to associate their susceptibility to develop T2D.
|
25839936 |
2015 |
rs750778014
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three novel KCNJ11 mutations, R27H, R192H and S116F117del, were identified in three families with early-onset type 2 diabetes mellitus.
|
24018988 |
2013 |
rs774714794
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three novel KCNJ11 mutations, R27H, R192H and S116F117del, were identified in three families with early-onset type 2 diabetes mellitus.
|
24018988 |
2013 |
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This study showed that rs5219 polymorphism of the KCNJ11 gene is an important risk factor for type 2 diabetes mellitus in a sample of the Syrian population.
|
31195986 |
2019 |
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
They also aid our understanding of how the Kir6.2-E23K variant predisposes to type 2 diabetes.
|
27118464 |
2016 |
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These variants may contribute significantly to the risk type 2 diabetes conferring insulin resistance of liver, muscle and fat (Pro12Ala) and a relative insulin secretory deficiency (Glu23Lys).
|
15715885 |
2005 |
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These data suggest that the E23K variant in KCNJ11 may influence the variability in the response of patients to sulfonylureas, thus representing an example of pharmacogenetics in type 2 diabetes.
|
16595597 |
2006 |
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
There was a believable evidence to verify that rs5219 variation was associated with T2DM.
|
29685723 |
2018 |
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The results suggest that E23K may have a greater effect on the development of T2D in female Chinese youth.
|
28449408 |
2018 |
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The polymorphism E23K on KCNJ11 that is associated with NIDDM was differentially distributed in the 2 cohorts.
|
17727257 |
2007 |
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The P12A variant in the PPARG gene and the E23K polymorphism in KCNJ11 are both known to influence individual predisposition to type 2 diabetes.
|
17994213 |
2008 |
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The KCNJ11 E23K polymorphism is not associated with genetic susceptibility to type 2 diabetes in the Iranian population; however, it may play a role in disease progression in the presence of obesity.
|
24460047 |
2014 |